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Article

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.

Immunology letters - 1 Dec 2014

Leifer Cynthia A, McConkey Cameron, Li Sha, Chassaing Benoit, Gewirtz Andrew T, Ley Ruth E

Abstract excerpt

Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on adaptive immunity. Loss of TLR5 has profound effects on the microbiota that include greater...

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Source

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Identifiers

PMID: 25284610
DOI: 10.1016/j.imlet.2014.07.017
PMCID: PMC4259828

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.PMID 25284610Read ↗

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