Article

Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD

2025-07-04

Abstract excerpt

<h4>Background</h4> Flagellin is the protein monomer of the bacterial flagellum, which confers motility, allowing bacteria to reach their favored niches. Flagellin is highly conserved across bacterial species and thus the target of the innate immune receptor Toll-like receptor 5 (TLR5). In the gut, bacterial flagellin agonizes human TLR5, triggering a pro-inflammatory response. However, the ability to bind and ac...

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Literature Corpus work: a66639ec-bf03-5488-9be1-297b9b888605
DOI: 10.1101/2025.06.30.660334

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