Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD.

Gut microbes - 31 Dec 2026

Bogdanova Anna A, Borbón-García Andrea, Ley Ruth E, Tyakht Alexander V

Abstract excerpt

Flagellin, the structural protein of bacterial flagella, activates the innate immune receptor Toll-like receptor 5 (TLR5). However, the ability of different flagellins to bind and stimulate TLR5 varies widely, suggesting that the composition of an individual's flagellin repertoire, defined as flagellome, may influence host-microbiome interactions and inflammation. Here, we developed FlaPro, a computational...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis, Ulcerative
Share to Crohn Disease
Share to Flagellin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Microbiome

Share to Inflammatory Bowel Diseases

Share to Machine Learning

Share to Multiomics

Share to Toll-Like Receptor 5

Source

Open in PubMed Open full text

Identifiers

PMID: 42424228
DOI: 10.1080/19490976.2026.2698917
PMCID: PMC13353774

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD.PMID 42424228Read ↗

Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBDSemantic proximity Read ↗

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5Semantic proximity Read ↗

Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian LineagesSemantic proximity Read ↗

Convergent losses of <i>TLR5</i> suggest altered extracellular flagellin detection in four mammalian lineagesSemantic proximity Read ↗

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation.Semantic proximity Read ↗

Mucosal interplay among commensal and pathogenic bacteria: Lessons from flagellin and Toll‐like receptor 5Semantic proximity Read ↗

A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin.Semantic proximity Read ↗

Diversity of motility gene signatures distinguishes commensal Clostridia that elicit divergent host immune responsesSemantic proximity Read ↗

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndromeSemantic proximity Read ↗

Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro.Semantic proximity Read ↗

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.Semantic proximity Read ↗

Elevated flagellin-specific immunoglobulins in Crohn's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.