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Article

A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.

The Journal of experimental medicine - 19 Feb 2007

Andersen-Nissen Erica, Smith Kelly D, Bonneau Richard, Strong Roland K, Aderem Alan

Abstract excerpt

The molecular basis for Toll-like receptor (TLR) recognition of microbial ligands is unknown. We demonstrate that mouse and human TLR5 discriminate between different flagellins, and we use this difference to map the flagellin recognition site on TLR5 to 228 amino acids of the extracellular domain. Through molecular modeling of the TLR5 ectodomain, we identify two conserved surface-exposed regions. Mutagenesis...

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Source

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Identifiers

PMID: 17283206
DOI: 10.1084/jem.20061400
PMCID: PMC2118731

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin.PMID 17283206Read ↗

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A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.Semantic proximity Read ↗

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