Article

Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity and tumor-specific looping-mediated biological pathways

2024-03-13

Abstract excerpt

<h4>SUMMARY</h4> Current knowledge in three-dimensional (3D) chromatin regulation in normal and disease states was mostly accumulated through Hi-C profiling in in vitro cell culture system. The limitations include failing to recapitulate disease-specific physiological properties and often lacking clinically relevant disease microenvironment. In this study, we conduct tissue-specific Hi-C profiling in a pilot coh...

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Literature Corpus work: 7afffd42-ad8c-572f-a912-5fa0bfd195a8
DOI: 10.1101/2024.03.13.584872

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