Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance

17 Sept 2021

Abstract excerpt

BACKGROUND: Organoids or spheroids have emerged as a physiologically relevant in vitro preclinical model to study patient-specific diseases. A recent study used spheroids of MCF10 cells to model breast cancer progression and identified targetable alterations more similar to those in vivo. Thus, it is practical and essential to explore and characterize the spheroids of the commonly used human breast cancer (BC)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Hippo pathway signaling and YAP/TAZ
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34535185
DOI: 10.1186/s13148-021-01167-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistancePMID 34535185Read ↗

Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity and tumor-specific looping-mediated biological pathwaysSemantic proximity Read ↗

The 3D genomic landscape of differential response to EGFR/HER2 inhibition in endocrine-resistant breast cancer cellsSemantic proximity Read ↗

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic opportunitiesSemantic proximity Read ↗

Unveiling Epigenetic Vulnerabilities in Triple-Negative Breast Cancer through 3D Organoid Drug ScreeningSemantic proximity Read ↗

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancerSemantic proximity Read ↗

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.Semantic proximity Read ↗

A living biobank of canine mammary tumor organoids as a comparative model for human breast cancerSemantic proximity Read ↗

Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene DiscoverySemantic proximity Read ↗

Breast Cancer Organoids Model Patient-Specific Response to Drug TreatmentSemantic proximity Read ↗

Breast tumour organoids: promising models for the genomic and functional characterisation of breast cancerSemantic proximity Read ↗

Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropismSemantic proximity Read ↗

Genome-wide analysis uncovers high frequency, strong differential chromosomal interactions and their associated epigenetic patterns in E2-mediated gene regulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.