Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.

doi:10.1073/pnas.2322068121

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Article

Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jul 2024

Shah Osama Shiraz, Nasrazadani Azadeh, Foldi Julia, Atkinson Jennifer M, Kleer Celina G, McAuliffe Priscilla F, Johnston Tyler J, Stallaert Wayne, da Silva Edaise M, Selenica Pier, Dopeso Higinio, Pareja Fresia, Mandelker Diana, Weigelt Britta, Reis-Filho Jorge S, Bhargava Rohit, Lucas Peter C, Lee Adrian V, Oesterreich Steffi

Abstract excerpt

Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadherin positive ductal and E-cadherin negative lobular morphologies within the same tumor, posing challenges with regard to anticipated clinical management. It remains unclear whether these distinct morphologies also have distinct biology and risk of recurrence. Our spatially resolved...

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PMID: 39042692
DOI: 10.1073/pnas.2322068121
PMCID: PMC11295029

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CDH1
MYC

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