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Spatial and Multi-Omics Analysis of Human Breast Cancer Reveals the Spatiotemporal Dynamics of Basal Layer Disruption

2026-08-11

Abstract excerpt

When breast cancer invasion begins and how tumor cells breach the basal barrier remain poorly defined. We profiled normal mammary ducts, ductal hyperplasia (DH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma using spatial transcriptomics, spatial proteomics and five bulk-omics layers, alongside an independent longitudinal lesion cohort. Cross-sectionally, basal/myoepithelial continuity declined mos...

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Literature Corpus work
cb7ff23e-148b-5d35-9573-b08c4ac7ec29
DOI
10.64898/2026.08.10.744069
Open publication

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Spatial and Multi-Omics Analysis of Human Breast Cancer Reveals the Spatiotemporal Dynamics of Basal Layer DisruptionDOI 10.64898/2026.08.10.744069
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