Article

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations

2023-09-12

Abstract excerpt

Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadherin positive ductal and E-cadherin negative lobular morphologies within the same tumor, posing challenges with regard to anticipated clinical management. It remains unclear whether these distinct morphologies also have distinct biology and risk of recurrence. Our spatially-resolved transcriptomic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 298a6200-09cf-58d0-b4b9-2c134f09fa52
DOI: 10.1101/2023.09.09.557013

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutationsDOI 10.1101/2023.09.09.557013Read

Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.Semantic proximity Read

Cellular stemness identifies high-risk ductal carcinoma <i>in situ</i> and offers a therapeutic interception opportunitySemantic proximity Read

Invasive lobular carcinoma of the breast: the increasing importance of this special subtype.Semantic proximity Read

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.Semantic proximity Read

A spatially resolved single cell genomic atlas of the adult human breastSemantic proximity Read

Spatial and Multi-Omics Analysis of Human Breast Cancer Reveals the Spatiotemporal Dynamics of Basal Layer DisruptionSemantic proximity Read

Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancerSemantic proximity Read

The Genomic Landscape of Lobular Breast CancerSemantic proximity Read

Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology.Semantic proximity Read

Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?Semantic proximity Read

Single cell transcriptomic heterogeneity in invasive ductal and lobular breast cancer cellsSemantic proximity Read

Molecular features of luminal breast cancer defined through spatial and single‐cell transcriptomicsSemantic proximity Read