Article

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets

2024-07-08

Abstract excerpt

Biliary tract cancers (BTCs) are a group of deadly malignancies encompassing intrahepatic and extrahepatic cholangiocarcinoma, gallbladder carcinoma, and ampullary carcinoma. Here, we present the integrative analysis of 63 BTC cell lines via multi-omics clustering and genome- scale CRISPR screens, providing a platform to illuminate BTC biology and inform therapeutic development. We identify dependencies broadly en...

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Literature Corpus work: 5718d9a7-730e-5767-bca4-130c0f5f96da
DOI: 10.1101/2024.07.04.601970

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