Article

Identification of disease-specific vulnerability states at the single-cell level

2024-12-09

Abstract excerpt

<h4>SUMMARY</h4> Intratumor heterogeneity in glioblastoma (GBM) impedes successful treatment as it is not obvious which tumor cells should be targeted. Here, we posit that single-cell-resolution transcriptomic data can be integrated with loss-of-function screens to identify the most critical cells to target within a tumor. We parsed CRISPR screen data from the Dependency Map (DepMap) Consortium and identified a G...

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Literature Corpus work: 3c530db0-5d9f-564b-9940-ccfbd6b0ddc7
DOI: 10.1101/2024.12.04.626873

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