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Changes in the Transcriptome and Synthetic Lethal Dependencies Following <i>KRAS</i> Mutant Expression Reveal Profound Tissue-Specificity

2026-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic KRAS mutations exhibit a striking tissue-restricted tropism, occurring with high frequency in pancreatic, colorectal, and lung adenocarcinomas while remaining rare in other lineages. The molecular basis for why these specific tissues are uniquely permissive to KRAS transformation, and how this context shapes therapeutic vulnerabilities, remains poorly defined. Here, we utilized CRISPR-...

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Literature Corpus work
9894a37f-7057-5a1b-84e0-1db738faea9c
DOI
10.64898/2026.04.30.721990
Open publication

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Changes in the Transcriptome and Synthetic Lethal Dependencies Following <i>KRAS</i> Mutant Expression Reveal Profound Tissue-SpecificityDOI 10.64898/2026.04.30.721990
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