Article

S100A9 Promotes Resistance to Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma by Degrading PARP1 and Activating the STAT3/PD-L1 Pathway

2025-01-14

Abstract excerpt

<title>Abstract</title> <p>Background Immune checkpoint inhibitors (ICIs), such as anti-programmed cell death protein-1 (PD-1) immunotherapy, have emerged as promising treatments for advanced hepatocellular carcinoma (HCC), significantly improving clinical outcomes. However, resistance to ICIs remains a major challenge, and the underlying mechanisms of this resistance are not yet fully understood. This study aim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7afdfc6d-7f3b-55c3-b259-0b208239a3d2
DOI: 10.21203/rs.3.rs-5797937/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

S100A9 Promotes Resistance to Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma by Degrading PARP1 and Activating the STAT3/PD-L1 PathwayDOI 10.21203/rs.3.rs-5797937/v1Read

Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy.Semantic proximity Read

Mechanisms of drug resistance in hepatocellular carcinomaSemantic proximity Read

Transcriptomic Profiling Identifies CSNK1E as a Key Mediator of Sorafenib Resistance in Hepatocellular CarcinomaSemantic proximity Read

Systematic decoding of the resistance mechanisms and therapeutic vulnerabilities in TKI-resistant hepatocellular carcinomaSemantic proximity Read

Survivin inhibition induces PD-L1 expression through cGAS stabilization and attenuates antitumor immunitySemantic proximity Read

Roles of S100 family members in drug resistance in tumors: Status and prospectsSemantic proximity Read

Association Analysis of CPSF4-PRKDC Co-expression with Poor Prognosis, Immune Microenvironment Characteristics, and Sorafenib Sensitivity in Hepatocellular CarcinomaSemantic proximity Read

Multi-omics Analysis Reveals the Anti-tumor Efficacy of Calycosin in Nasopharyngeal Carcinoma and its Mechanism of Overcoming ABCC1-Mediated ResistanceSemantic proximity Read

Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells.Semantic proximity Read

Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed MelanomaSemantic proximity Read

Mechanism of ASIC4 in Regulating MHC-I-Mediated Immune Evasion in Pancreatic CancerSemantic proximity Read

Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma.Semantic proximity Read