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Article

Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy.

Gut - 10 May 2024

Cai Ning, Cheng Kun, Ma Yue, Liu Sha, Tao Ran, Li Yani, Li Danfeng, Guo Bin, Jia Wenlong, Liang Huifang, Zhao Jianping, Xia Limin, Ding Ze-Yang, Chen Jinhong, Zhang Wanguang

Abstract excerpt

OBJECTIVE: The gain of function (GOF) CTNNB1 mutations (CTNNB1 GOF ) in hepatocellular carcinoma (HCC) cause significant immune escape and resistance to anti-PD-1. Here, we aimed to investigate the mechanism of CTNNB1 GOF HCC-mediated immune escape and raise a new therapeutic strategy to enhance anti-PD-1 efficacy in HCC. DESIGN: RNA sequencing was performed to identify the key downstream genes of CTNNB1 GOF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38123979
DOI: 10.1136/gutjnl-2023-331342
PMCID: PMC11103337

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