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Article

Transcriptomic Profiling Identifies CSNK1E as a Key Mediator of Sorafenib Resistance in Hepatocellular Carcinoma

2025-12-04

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Sorafenib is the standard first-line therapy for advanced hepatocellular carcinoma (HCC), yet its clinical efficacy is often limited by primary or acquired resistance. The molecular mechanisms underlying this resistance remain poorly understood. Casein kinase 1 epsilon (CSNK1E), a known regulator of WNT/β-catenin signaling, may play a role in drug resistance,...

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Literature Corpus work
f6034a90-0eb2-583d-aa2f-0aace34dc745
DOI
10.21203/rs.3.rs-7049920/v1
Open publication

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Transcriptomic Profiling Identifies CSNK1E as a Key Mediator of Sorafenib Resistance in Hepatocellular CarcinomaDOI 10.21203/rs.3.rs-7049920/v1
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