Article

Systematic decoding of the resistance mechanisms and therapeutic vulnerabilities in TKI-resistant hepatocellular carcinoma

2026-03-03

Abstract excerpt

<title>Abstract</title> <p>Drug resistance to multiple tyrosine kinase inhibitors (TKIs) is a major issue during clinical management of hepatocellular carcinoma (HCC). Here, through multiplexed in vitro and in vivo CRISPR knockout and base editing screens, we elucidate the resistance mechanisms of HCC to typical TKIs (sorafenib, lenvatinib and regorafenib). Multiple genetic or epigenetic alterations can drive res...

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Literature Corpus work: 8a13570a-197e-5eab-b675-a61d6607d131
DOI: 10.21203/rs.3.rs-8651907/v1

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