Article

Survivin inhibition induces PD-L1 expression through cGAS stabilization and attenuates antitumor immunity

2026-05-01

Abstract excerpt

<h4>Background</h4> Survivin is a mitotic regulator frequently overexpressed in human cancers and an attractive therapeutic target. However, how Survivin inhibition influences tumor immune regulation remains incompletely understood. This study aimed to investigate whether Survivin inhibition modulates antitumor immunity and to elucidate the underlying mechanisms. <h4>Methods</h4> Programmed death-ligand 1 (PD-L1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3865cefc-cda7-50b6-a7de-388e3eedc0b3
DOI: 10.64898/2026.04.29.721504

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Survivin inhibition induces PD-L1 expression through cGAS stabilization and attenuates antitumor immunityDOI 10.64898/2026.04.29.721504Read

Mechanisms of immune checkpoint inhibitors: insights into the regulation of circular RNAS involved in cancer hallmarksSemantic proximity Read

Using targeted therapy to promote a pro-inflammatory tumour microenvironment and anti-tumour immune response in high grade serous ovarian cancerSemantic proximity Read

Cell Cycle Activity Correlates with Increased Anti-Tumor Immunity in Diverse CancersSemantic proximity Read

PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signalingSemantic proximity Read

PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF–caspase 8–GSDMD/E axis in ovarian cancerSemantic proximity Read

Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic StrategiesSemantic proximity Read

Combination strategies with PD-1/PD-L1 blockade: current advances and future directionsSemantic proximity Read

Investigations of survivin: the past, present and futureSemantic proximity Read

Targeting the loss of cGAS / STING signaling in cancerSemantic proximity Read

S100A9 Promotes Resistance to Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma by Degrading PARP1 and Activating the STAT3/PD-L1 PathwaySemantic proximity Read

Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed MelanomaSemantic proximity Read

PD-1 immune checkpoint blockade enhances FLOT chemotherapy toxicity in oesophageal adenocarcinoma cells via immune-independent mechanismsSemantic proximity Read