Article

Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed Melanoma

2024-09-27

Abstract excerpt

Programmed Cell Death 1 (PD-1) signaling blockade effectively restores immune surveillance to treat melanoma. However, chronic interferon-gamma (IFNγ) -driven immune homeostatic mechanisms in melanoma cells contribute to immune evasion and acquired resistance. We previously demonstrated that poly ADP ribosyl polymerase 14 (PARP14), an IFNγ-responsive gene product, in part mediates IFNγ-driven resistance, as its in...

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Literature Corpus work: 53d9c79f-b071-5260-92a1-eba8e22f06aa
DOI: 10.1101/2024.09.26.615178

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