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Association Analysis of CPSF4-PRKDC Co-expression with Poor Prognosis, Immune Microenvironment Characteristics, and Sorafenib Sensitivity in Hepatocellular Carcinoma

2025-07-14

Abstract excerpt

<title>Abstract</title> <p>This study elucidates the synergistic oncogenic effects and clinical translational significance of Cleavage and Polyadenylation Specific Factor 4 (CPSF4) and the DNA repair kinase PRKDC in hepatocellular carcinoma (HCC). An analysis of the TCGA cohort revealed a significant positive correlation between CPSF4 and PRKDC expression in HCC (r = 0.31, P < 0.001), with patients exhibiting hig...

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Literature Corpus work
e0c000da-c524-5b8d-9b7d-ab2c3cc13950
DOI
10.21203/rs.3.rs-6819192/v1
Open publication

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