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Article

Elevated PDK1 Expression Drives PI3K/AKT/MTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma.

Cells - 18 Mar 2020

Bamodu Oluwaseun Adebayo, Chang Hang-Lung, Ong Jiann-Ruey, Lee Wei-Hwa, Yeh Chi-Tai, Tsai Jo-Ting

Abstract excerpt

Resistance to radiotherapy (IR), with consequent disease recurrence, continues to limit the efficacy of contemporary anticancer treatment for patients with hepatocellular carcinoma (HCC), especially in late stage. Despite accruing evidence implicating the PI3K/AKT signaling pathway in cancer-promoting hypoxia, cancerous cell proliferation and radiotherapy-resistance, it remains unclear which molecular constituent...

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Identifiers

PMID: 32197467
DOI: 10.3390/cells9030746
PMCID: PMC7140693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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