Article

Mechanism of ASIC4 in Regulating MHC-I-Mediated Immune Evasion in Pancreatic Cancer

2025-11-13

Abstract excerpt

<title>Abstract</title> <p>Immune evasion is a major cause of the poor efficacy of therapies for pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which MHC-I downregulation leads to low infiltration of cytotoxic T lymphocytes in PDAC remains incompletely elucidated. This study aims to identify the molecules responsible for the low expression of MHC-I and potential novel therapeutic ta...

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Literature Corpus work: d9bb057d-980c-59ba-b750-34eb2040e26d
DOI: 10.21203/rs.3.rs-7975326/v1

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