Article

An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS

2025-08-25

Abstract excerpt

<h4>Summary</h4> To uncover molecular determinants of motor neuron degeneration and selective vulnerability in amyotrophic lateral sclerosis (ALS), we generated longitudinal single-nucleus transcriptomes and chromatin accessibility profiles of spinal motor neurons from the SOD1-G93A ALS mouse model. Vulnerable alpha motor neurons showed thousands of molecular changes, marking a transition into a novel cell state...

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Identifiers and source

Literature Corpus work: 7a9db48b-ed01-5dd4-acc7-403d94da27cd
DOI: 10.1101/2025.08.21.671404

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