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Spatial enrichment and genomic analyses reveal the link of NOMO1 with amyotrophic lateral sclerosis

20 Apr 2024

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease with uncertain genetic predisposition in most sporadic cases. The spatial architecture of cell types and gene expression are the basis of cell-cell interactions, biological function and disease pathology, but are not well investigated in the human motor cortex, a key ALS-relevant brain region. Recent studies indicated single nucleus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38643019
DOI: 10.1093/brain/awae123

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