Article

Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytes

2026-06-01

Abstract excerpt

<title>Abstract</title> <p>Amyotrophic lateral sclerosis (ALS) causes selective neurodegeneration in primary motor cortex, yet cell-type-specific molecular changes driving this vulnerability remain poorly understood. We present an integrated single-nucleus RNA- and ATAC-sequencing atlas of 778,330 nuclei from the primary motor cortex of 140 genetically characterised donors. ALS is associated with widespread trans...

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Literature Corpus work: 41285f82-67be-5e69-a0b9-1ce989bb3b59
DOI: 10.21203/rs.3.rs-9853460/v1

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