Article

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types

2020-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Despite the considerable progress in unraveling the genetic causes of amyotrophic lateral sclerosis (ALS), we do not fully understand the molecular mechanisms underlying the disease. We analyzed genome-wide data involving 78,500 individuals using a polygenic risk score approach to identify the biological pathways and cell types involved in ALS. This data-driven approach identified multiple aspec...

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Literature Corpus work: f738665a-93a9-5088-b58d-451586f0be52
DOI: 10.1101/2020.07.20.211276

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