Article

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral Sclerosis

2020-11-15

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) is an archetypal complex disease centered on progressive death of motor neurons. Despite heritability estimates of 52%, GWAS studies have discovered only seven genome-wide significant hits, which are relevant to <10% of ALS patients. To increase the power of gene discovery, we integrated motor neuron functional genomics with ALS genetics in a hierarchical Baye...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e16df911-addf-5492-a574-30f82cdc8e72
DOI: 10.1101/2020.11.14.382606

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Identification of the Genetic Basis of Amyotrophic Lateral SclerosisDOI 10.1101/2020.11.14.382606Read

Genome-wide identification of the genetic basis of amyotrophic lateral sclerosisSemantic proximity Read

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell typesSemantic proximity Read

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.Semantic proximity Read

Update on genetics of amyotrophic lateral sclerosis.Semantic proximity Read

Causal Inference of Genetic Variants and Genes in Amyotrophic Lateral SclerosisSemantic proximity Read

Amyotrophic lateral sclerosis: recent genetic highlights.Semantic proximity Read

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.Semantic proximity Read

Genetics of Amyotrophic Lateral SclerosisSemantic proximity Read

Partitioning the genetic architecture of amyotrophic lateral sclerosisSemantic proximity Read

Characterising the Genetic Landscape of Amyotrophic Lateral Sclerosis: A Catalogue and Assessment of Over 1,000 Published Genetic VariantsSemantic proximity Read

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology.Semantic proximity Read

ALS Genes in the Genomic Era and their Implications for FTD.Semantic proximity Read