Article
Single-nucleus multiome shows motor neuron glutamate overactivation in amyotrophic lateral sclerosis.
Brain : a journal of neurology - 7 Jul 2026
Takeuchi Eriko, Yasumizu Yoshiaki, Morita Junko, Ishikawa Masakazu, Ogawa Kotaro, Motooka Daisuke, Okuzaki Daisuke, Nagata Miho, Ishihara Yasuki, Miyashita Yohei, Asano Yoshihiro, Mori Kohji, Morii Eiichi, Beck Goichi, Saito Yuko, Murayama Shigeo, Mochizuki Hideki, Nagano Seiichi
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes motor neuron degeneration. However, the mechanisms underlying the selective vulnerability of motor neurons and the involvement of non-motor neuron cells in ALS remain unclear. To investigate ALS pathology at the cellular level, we performed a single-nucleus multiome analysis, including RNA sequencing and chromatin accessibility...
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