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Role of BET Proteins in Inflammation and CNS Diseases

16 Sept 2021

Abstract excerpt

Bromodomain and extra-terminal domain (BET) proteins consist of four mammalian members (BRD2, BRD3, BRD4, and BRDT), which play a pivotal role in the transcriptional regulation of the inflammatory response. Dysregulated inflammation is a key pathological process in various CNS disorders through multiple mechanisms, including NF-κB and Nrf2 pathways, two well-known master regulators of inflammation. A better...

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PMID: 34604312
DOI: 10.3389/fmolb.2021.748449

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