Article

Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation

2024-09-26

Abstract excerpt

<title>Abstract</title> <p>The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from several members of the NF-κB pathway. Thereby, CYLD is critical for the maintenance and differentiation of various immune cells. Despite the importance of the NF-κB pathway in microglia regulation, the role of CYLD in microglia has not been investigated so far. In this stud...

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Literature Corpus work: 838243a1-9af0-525a-9226-047cb28a9dc8
DOI: 10.21203/rs.3.rs-4978181/v1

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