Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation.

Journal of molecular medicine (Berlin, Germany) - 1 Nov 2024

Schramm Eva, Becker Vanessa, Palagi Ilaria, Müller Melanie, Rösler Thomas, Durak Feyza, Ebering Anna, Karram Khalad, von Stebut Esther, Schmeisser Michael J, Waisman Ari

Abstract excerpt

The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from several members of the NF-κB pathway. Thereby, CYLD is critical for the maintenance and differentiation of various immune cells. Despite the importance of the NF-κB pathway in microglia regulation, the role of CYLD in microglia has not been investigated so far. In this study, we investigated whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deubiquitinating Enzyme CYLD
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Lipopolysaccharides

Share to Mice, Transgenic

Share to Microglia

Share to Neuroinflammatory Diseases

Share to NF-kappa B

Source

Open in PubMed Open full text

Identifiers

PMID: 39302418
DOI: 10.1007/s00109-024-02489-7
PMCID: PMC11525298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation.PMID 39302418Read ↗

Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammationSemantic proximity Read ↗

BRD4 expression in microglia supports recruitment of T cells into the CNS and exacerbates EAESemantic proximity Read ↗

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.Semantic proximity Read ↗

The deubiquitinase activity of A20 is dispensable for NF-κB signaling.Semantic proximity Read ↗

Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALSSemantic proximity Read ↗

Cyld aborts hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axisSemantic proximity Read ↗

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.Semantic proximity Read ↗

The E3 ligase c-Cbl modulates microglial phenotypes and contributes to Parkinson’s disease pathologySemantic proximity Read ↗

Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitisSemantic proximity Read ↗

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.Semantic proximity Read ↗

Role of CYLD in brain physiology and pathologySemantic proximity Read ↗

Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.