Article
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders.
Nature neuroscience - 1 Aug 2022
Bryois Julien, Calini Daniela, Macnair Will, Foo Lynette, Urich Eduard, Ortmann Ward, Iglesias Victor Alejandro, Selvaraj Suresh, Nutma Erik, Marzin Manuel, Amor Sandra, Williams Anna, Castelo-Branco Gonçalo, Menon Vilas, De Jager Philip, Malhotra Dheeraj
Abstract excerpt
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types. In this study, we performed an eQTL analysis using single-nuclei RNA sequencing from 192 individuals in eight brain cell types derived from the prefrontal cortex, temporal cortex and white matter....
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