Article

High cell-type specificity of eQTLs revealed by single-nucleus analyses of brain and blood

2025-11-28

Abstract excerpt

Identifying causal mechanisms from genome-wide association studies (GWAS) requires an understanding of how disease-associated genetic variants influence gene expression in specific cell types. Here, we present scMetaBrain, a large-scale single-nucleus RNA-sequencing (snRNA-seq) resource derived using 1,260 samples from 785 individuals spanning 10 brain datasets. By analyzing 3.9 million transcriptomes, we identifi...

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Literature Corpus work: 708bd27a-77fe-586c-ad17-b2aba873fda6
DOI: 10.1101/2025.11.26.689911

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