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Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathology

2025-12-11

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with an unknown etiology. To pinpoint new disease-relevant cell states and their molecular profiles, we performed an in-depth investigation of multimodal single-cell datasets comprising ∼2.1 million peripheral blood mononuclear cells from 346 donors. By resolving 123 fine-grained cell states across 27 cell types, we identified previously uncharacte...

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Literature Corpus work
1b3ede5a-bd2e-5809-bfa2-d653443bedc2
DOI
10.64898/2025.12.08.693110
Open publication

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Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathologyDOI 10.64898/2025.12.08.693110
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