Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

6 Mar 2023

Abstract excerpt

Background Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease affecting multiple organs and tissues with high cellular heterogeneity. CD8 + T cell activity is involved in the SLE pathogenesis. However, the cellular heterogeneity and the underlying mechanisms of CD8 + T cells in SLE remain to be identified. Methods Single-cell RNA sequencing (scRNA-seq) of PBMCs from a SLE family pedigree...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Phagocytosis and Immune Regulation
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36893588
DOI: 10.1016/j.ebiom.2023.104507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosusPMID 36893588Read ↗

Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathologySemantic proximity Read ↗

Transcriptome sequencing reveals novel molecular features of SLE severitySemantic proximity Read ↗

Immune cell and TCR/BCR repertoire profiling in systemic lupus erythematosus patients by single-cell sequencingSemantic proximity Read ↗

Single Cell and Transcriptomic Analysis of Regulatory Mechanisms of Key Genes in Systemic Lupus ErythematosusSemantic proximity Read ↗

Type I interferon drives dysfunction of a distinct CD8+ HLA-DRB1+ T cell subset in systemic lupus erythematosusSemantic proximity Read ↗

The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell ResolutionSemantic proximity Read ↗

Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosusSemantic proximity Read ↗

Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosusSemantic proximity Read ↗

Variant-to-function mapping in lupus links <i>IL12A</i> to the expansion of disease-associated B cells with a cytotoxic programSemantic proximity Read ↗

Recent insights into the role of innate immunity in lupusSemantic proximity Read ↗

TRIM5 Promotes Systemic Lupus Erythematosus Through CD4(+) T Cells and MacrophageSemantic proximity Read ↗

Region- and variance-based DNA methylation analyses reveal novel disease genes and pathways for systemic lupus erythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.