?-amyloid binds to p75NTRand activates NF?B in human neuroblastoma cells

Abstract excerpt

Amyloid beta peptide (Abeta), a proteolytic fragment of the amyloid precursor protein (APP), is a major component of the plaques found in the brain of Alzheimer's disease (AD) patients. These plaques are thought to cause the observed loss of cholinergic neurons in the basal forebrain of AD patients. In these neurons, particularly those of the nucleus basalis of Meynert, an up-regulation of 75kD-neurotrophin...

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• Cell death mechanisms and regulation
• Neuroblastoma Research and Treatments
• NF-κB Signaling Pathways