Article

p75 neurotrophin receptor signaling through the RhoA/ROCK pathway contributes to Alzheimer’s Disease tauopathy

2026-02-23

Abstract excerpt

Therapeutic development in Alzheimer’s Disease (AD) has for the most part been focused on reducing β-amyloid load. Nevertheless, neurofibrillary tangles (NFTs), produced by aggregation of hyper-phosphorylated Tau protein, correlate with neurodegeneration and cognitive impairment significantly better than amyloid accumulation in AD patients. Here we report that P301S mice, a model of AD tauopathy, carrying mutant v...

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Literature Corpus work: b526b73a-70ef-5723-8599-752f3ea4c5f4
DOI: 10.64898/2026.02.22.707328

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