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Article

Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease.

Journal of negative results in biomedicine - 12 Jan 2012

Cheng Hui-Chi, Sun Yu, Lai Liang-Chuan, Chen Shih-Yuan, Lee Wen-Chung, Chen Jen-Hau, Chen Ta-Fu, Chen Hua-Hsiang, Wen Li-Li, Yip Ping-Keung, Chu Yi-Min, Chen Wei J, Chen Yen-Ching

Abstract excerpt

BACKGROUND: Loss of basal forebrain cholinergic neurons is attributable to the proapoptotic signaling induced by nerve growth factor receptor (NGFR) and may link to Alzheimer's disease (AD) risk. Only one study has investigated the association between NGFR polymorphisms and the risk of AD in an Italian population. Type 2 diabetes mellitus (DM) may modify this association based on previous animal and epidemiologic...

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Identifiers

PMID: 22236693
DOI: 10.1186/1477-5751-11-5
PMCID: PMC3362783

Genes

NGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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