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Article

Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid-β deposition in the brain.

CNS neuroscience & therapeutics - 1 Dec 2022

He Chen-Yang, Wang Zuo-Teng, Shen Ying-Ying, Shi An-Yu, Li Hui-Yun, Chen Dong-Wan, Zeng Gui-Hua, Tan Cheng-Rong, Yu Jin-Tai, Zeng Fan, Wang Yan-Jiang

Abstract excerpt

INTRODUCTION AND AIMS: Alzheimer's disease (AD) is the most common form of dementia with a complex genetic background. The cause of sporadic AD (sAD) remains largely unknown. Increasing evidence shows that genetic variations play a crucial role in sAD. P75 neurotrophin receptor (p75NTR, encoded by NGFR) plays a critical role in the pathogenesis of AD. Yet, the relationship between NGFR gene polymorphisms and AD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36074475
DOI: 10.1111/cns.13965
PMCID: PMC9627368

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