Article

Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons

2019-05-07

Abstract excerpt

<h4>Background</h4> Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to effects of polygenic susceptibility, with inherited liability exhibiting distinct sex differences in phenotypic expression. Attempts to model ASD in human cellular systems have principally involved rare de novo mutations associated with ASD ph...

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Literature Corpus work: 79ea8c9c-68a8-5da3-acc4-163d60f7e3a0
DOI: 10.1101/620807

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