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Article

Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets.

Molecular autism - 8 Feb 2021

Pintacuda Greta, Martín Jacqueline M, Eggan Kevin C

Abstract excerpt

Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by impaired social interactions as well as the presentation of restrictive and repetitive behaviors. ASD is highly heritable but genetically heterogenous with both common and rare genetic variants collaborating to predispose individuals to the disorder. In this review, we synthesize recent efforts to develop human...

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Identifiers

PMID: 33557935
DOI: 10.1186/s13229-021-00417-x
PMCID: PMC7869517

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