Article
Development of a human iPSC and patient phenotyping resource for preclinical investigations of neurodevelopmental disorders.
Stem cell research - 1 Sept 2026
Chen Cidi, Afshar-Saber Wardiya, Iglesias Isabela, Kim Kristina, Lewis Becca, Srinivasan Gayathri, Chen Celeste, Hirsh Remi, Guardado Ryan, Polanco Taryn, Swanson Amanda, Norabuena Erika, Whye Dosh, Jain Ashish, Cai Chunhui, Sun Liang, Chopra Maya, Chen Ivy, Iannello Grazia, Rozumny Brian, Hanson Ellen, Sahin Mustafa, Buttermore Elizabeth D
Abstract excerpt
In this manuscript, we report the development of a comprehensive resource designed to harness the transformative potential of patient-derived induced pluripotent stem cells (iPSCs) to advance the study of neurodevelopmental disorders (NDDs). Using CRISPR-Cas-mediated genome editing, the Human Neuron Core generated a repository comprising 29 isogenic iPSC pairs, two sex-matched parental control iPSC pairs, and one...
Read the complete abstract on PubMedTopics
- Humans
- Induced Pluripotent Stem Cells
- Neurodevelopmental Disorders
- Phenotype