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Article

Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons.

Molecular autism - 1 Jan 2019

Lewis Emily M A, Meganathan Kesavan, Baldridge Dustin, Gontarz Paul, Zhang Bo, Bonni Azad, Constantino John N, Kroll Kristen L

Abstract excerpt

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to the effects of polygenic susceptibility, with inherited liability exhibiting distinct sex differences in phenotypic expression. Attempts to model ASD in human cellular systems have principally involved rare de novo mutations associated with ASD...

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Identifiers

PMID: 31893020
DOI: 10.1186/s13229-019-0306-0
PMCID: PMC6936127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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