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Article

Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia.

Oncogene - 17 Aug 2017

Sumner E T, Chawla A T, Cororaton A D, Koblinski J E, Kovi R C, Love I M, Szomju B B, Korwar S, Ellis K C, Grossman S R

Abstract excerpt

Overexpression of the transcriptional coregulators C-terminal binding proteins 1 and 2 (CtBP1 and 2) occurs in many human solid tumors and is associated with poor prognosis. CtBP modulates oncogenic gene expression programs and is an emerging drug target, but its oncogenic role is unclear. Consistent with this oncogenic potential, exogenous CtBP2 transformed primary mouse and human cells to anchorage independence...

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Identifiers

PMID: 28414304
DOI: 10.1038/onc.2017.106
PMCID: PMC5561459

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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