Article

Prognostic Impact of TP53 Mutations in Newly Diagnosed Pediatric B-Cell Acute Lymphoblastic Leukemia: A Single-Center Study from China

2025-11-10

Abstract excerpt

<title>Abstract</title> <p> Background: Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with cure rates exceeding 90% under modern treatment protocols. Nevertheless, 10–20% of patients relapse, and post-relapse survival remains poor. Although <italic>TP53</italic> mutations are rare at initial diagnosis, they are enriched at relapse and have been implicated as adverse prognostic mar...

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Literature Corpus work: 79a2fb9c-1854-5904-b6e2-5ba4adedce7f
DOI: 10.21203/rs.3.rs-7616674/v1

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