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Clinical Characteristics and Outcomes of Pediatric B-Cell Acute Lymphoblastic Leukemia Harboring TP53 Mutations: A Single-Center Retrospective Study.

Pediatric blood & cancer - 1 Jun 2026

Yin Jinlei, Zhang Yuanyuan, Lin Wei, Wu Ying, Qi Peijing, Zhang Mingying, Li Zhigang, Zhang Ruidong

Abstract excerpt

BACKGROUND: This study analyzed the genetic mutation spectrum, clinical characteristics, and therapeutic outcomes of pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients harboring TP53 mutations. METHODS: A retrospective analysis was conducted on 32 pediatric B-ALL patients with TP53 mutations admitted to Beijing Children's Hospital, Capital Medical University, from November 2019 to August 2025....

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Identifiers

PMID: 41879019
DOI: 10.1002/1545-5017.70276

Genes

TP53
EFS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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