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Article

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.

British journal of cancer - 11 Jul 2017

Forero-Castro Maribel, Robledo Cristina, Benito Rocío, Bodega-Mayor Irene, Rapado Inmaculada, Hernández-Sánchez María, Abáigar María, Maria Hernández-Sánchez Jesús, Quijada-Álamo Miguel, María Sánchez-Pina José, Sala-Valdés Mónica, Araujo-Silva Fernanda, Kohlmann Alexander, Luis Fuster José, Arefi Maryam, de Las Heras Natalia, Riesco Susana, Rodríguez Juan N, Hermosín Lourdes, Ribera Jordi, Camos Guijosa Mireia, Ramírez Manuel, de Heredia Rubio Cristina Díaz, Barragán Eva, Martínez Joaquín, Ribera José M, Fernández-Ruiz Elena, Hernández-Rivas Jesús-María

Abstract excerpt

BACKGROUND: In B-cell precursor acute lymphoblastic leukaemia (B-ALL), the identification of additional genetic alterations associated with poor prognosis is still of importance. We determined the frequency and prognostic impact of somatic mutations in children and adult cases with B-ALL treated with Spanish PETHEMA and SEHOP protocols. METHODS: Mutational status of hotspot regions of TP53, JAK2, PAX5, LEF1,...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to Gene Expression Regulation, Neoplastic

Share to High-Throughput Nucleotide Sequencing

Share to Janus Kinase 2

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, Cytokine

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 28557976
DOI: 10.1038/bjc.2017.152
PMCID: PMC5520505

Genes

EFS
JAK2
CRLF2
PAX5
ABL1
BCR
ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.PMID 28557976Read ↗

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