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Article

Impact of TP53 mutations and their variant allele frequency in adults with newly diagnosed acute lymphoblastic leukemia.

Blood - 29 Jan 2026

Azevedo Roberta S, Jabbour Elias, Kantarjian Hagop M, Lavu Sravanthi, Loghavi Sanam, Jain Nitin, Sasaki Koji, Garris Rebecca S, Takahashi Koichi, Ravandi Farhad, Short Nicholas J

Abstract excerpt

ABSTRACT: TP53 mutations are associated with unfavorable survival in many hematologic malignancies. However, the impact of TP53 mutations and their variant allele frequency (VAF) in acute lymphoblastic leukemia (ALL) remains unclear. We retrospectively analyzed TP53 mutations and their VAF in newly diagnosed ALL. The overall incidence of TP53 mutations was 17.2%; TP53 mutations were more common in older patients...

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Identifiers

PMID: 41335402
DOI: 10.1182/blood.2025030498
PMCID: PMC12982969

Genes

TP53
EFS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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