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Article

Clinical and molecular characterization of TP53-mutant acute lymphoblastic leukemia in adults.

Blood cancer journal - 14 Aug 2025

Harris Ethan J, Karaoglu Diren Arda, Sukhanova Madina, Abaza Yasmin, Karantanos Theodoros, Eisfeld Ann-Kathrin, Anderson Clare, Lin Chenyu, Moreno Vanegas Yenny A, Badar Talha, Coltoff Alexander, Knepper Todd C, Ozkaya Neval, Youshanlouei Hamed Rahmani, Cetin Sinan, Patel Anand A, DuVall Adam S, Drazer Michael W, Wang Peng, Tjota Melissa, Segal Jeremy P, Venkataraman Girish, Gurbuxani Sandeep, Cheng Jason X, Arber Daniel A, Larson Richard A, Odenike Olatoyosi, Webster Jonathan, Shah Bijal, Stock Wendy, Saygin Caner

Abstract excerpt

TP53-mutant acute lymphoblastic leukemia (ALL) in adults is a high-risk subtype with poor outcomes, yet its molecular landscape and clinical implications remain incompletely defined. In this multi-institutional study of 830 adult ALL patients treated at eight academic centers between 2010 and 2024, we demonstrated that TP53 mutations are independent predictors of inferior overall survival in both B-ALL (median,...

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Identifiers

PMID: 40813576
DOI: 10.1038/s41408-025-01350-5
PMCID: PMC12354737

Genes

TP53
CD19
CD22
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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