Article

Clinical Significance of TP53, PAX5, and JAK2 gene mutation in Pediatric Acute Lymphoblastic Leukemia

2023-08-18

Abstract excerpt

<h4>Background: </h4> Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide. Developed countries have a 90% 5-year overall survival rate with proper treatment, while LMICs have a poor rate of around 30-50%. The research aims to identify mutations in frequently mutated genes’ hotspot regions to design appropriate treatment plans based on patients’ somatic makeup. <h4>Methods: <...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1f317420-2d21-5a61-8f4c-ffca280377eb
DOI: 10.22541/au.169235303.31594994/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clinical Significance of TP53, PAX5, and JAK2 gene mutation in Pediatric Acute Lymphoblastic LeukemiaDOI 10.22541/au.169235303.31594994/v1Read

Clinical Significance of TP53, PAX5, and JAK2 gene mutation in Pediatric Acute Lymphoblastic LeukemiaSemantic proximity Read

Prognostic Impact of TP53 Mutations in Newly Diagnosed Pediatric B-Cell Acute Lymphoblastic Leukemia: A Single-Center Study from ChinaSemantic proximity Read

Clinical Characteristics and Outcomes of Pediatric B-Cell Acute Lymphoblastic Leukemia Harboring TP53 Mutations: A Single-Center Retrospective Study.Semantic proximity Read

Characteristics of Molecular Genetic Mutations and Their Correlation with Prognosis in Adolescent and Adult Patients with Acute Lymphoblastic Leukemia.Semantic proximity Read

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.Semantic proximity Read

Impact of TP53 gene variants on prognosis and survival of childhood acute lymphoblastic leukemia.Semantic proximity Read

[Clinical and prognostic values of TP53 mutation in patients with B-lineage acute lymphoblastic leukemia].Semantic proximity Read

Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemiaSemantic proximity Read

[Spectrum of somatic mutations and their prognostic significance in adult patients with B cell acute lymphoblastic leukemia].Semantic proximity Read

[Gene Mutation in Acute Lymphoblastic Leukemia by DNA Sequencing].Semantic proximity Read

[Mutation and expression of PAX5 gene in adult acute lymphoblastic leukemia].Semantic proximity Read

Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia.Semantic proximity Read