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TP53 and RB1 alterations characterize poor prognostic subgroups in pediatric acute myeloid leukemia.

Genes, chromosomes & cancer - 1 Jul 2023

Hara Yusuke, Shiba Norio, Yoshida Kenichi, Yamato Genki, Kaburagi Taeko, Shiraishi Yuichi, Ohki Kentaro, Shiozawa Yusuke, Kawamura Machiko, Kawasaki Hirohide, Sotomatsu Manabu, Takizawa Takumi, Matsuo Hidemasa, Shimada Akira, Kiyokawa Nobutaka, Tomizawa Daisuke, Taga Takashi, Ito Etsuro, Horibe Keizo, Miyano Satoru, Adachi Souichi, Taki Tomohiko, Ogawa Seishi, Hayashi Yasuhide

Abstract excerpt

Pediatric acute myeloid leukemia (AML) is a poor prognostic subtype of pediatric leukemia. However, the detailed characteristics of many genetic abnormalities are yet to be established in this disease. Although TP53 and RB1 are established as representative tumor suppressor genes in various cancers, alterations of these two genes, especially RB1, have not been characterized in pediatric AML. We performed...

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PMID: 37102302
DOI: 10.1002/gcc.23147

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